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Symbol
Name
ID 		Nr0b1
nuclear receptor subfamily 0, group B, member 1
MGI:1352460
Phenotype annotations related to reproductive system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Hypogonadotropic hypogonadism
Cryptorchidism
Sex reversal
Azoospermia
Oligozoospermia
Disease(s) Associated with NR0B1
46,XY sex reversal 2
X-linked adrenal hypoplasia congenita

Mouse Phenotypes
decreased male germ cell number
absent germ cells
increased Sertoli cell proliferation
polyovular ovarian follicle
abnormal testis morphology
rete testis obstruction
abnormal peritubular myoid cell morphology
decreased number of peritubular myoid cells
abnormal seminiferous tubule epithelium morphology
ectopic Sertoli cells
dilated seminiferous tubule
seminiferous tubule degeneration
abnormal Sertoli cell development
abnormal testis cord formation
disorganized testis cords
abnormal Leydig cell morphology
abnormal fetal Leydig cell differentiation
ectopic Leydig cells
increased Leydig cell number
decreased testis weight
small testis
increased testis tumor incidence
abnormal reproductive system morphology
abnormal spermatogenesis
abnormal efferent ductules of testis morphology
ovotestis
abnormal primary sex determination
primary sex reversal
male infertility
Availability Mouse Genotype
Nr0b1tm1.1Lja/Nr0b1tm1.1Lja
Nr0b1em2(IMPC)Wtsi/Y
Nr0b1tm1.1Lja/Y
Nr0b1tm1Lja/Y ! ! !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory